Dr Serena Low Kiat Mun
Consultant, Clinical Research Unit, KTPH
Biography
Dr Serena Low has specialized training in the field of Public Health. She has a strong research interest in geriatric syndromes in type 2 diabetes and completed PhD (Medicine) in 2023.
Research Interests
Cognitive impairment, Frailty and Sarcopenia
Type 2 Diabetes and its complications
Member
Research Assistants: Ms Theedaraj Bun Chuan, Ms Lim Jiaqing, Ms Alicia Miyuki Lim Hui
Clinical Research Coordinator: Ms Audris Chia Kui En
Collaborations
LKC-Medicine
NHG HSOR
Link to Google Scholar
https://scholar.google.com/citations?user=HLoIN-gAAAAJ&hl=en
low.serena.km@nhghealth.com.sg
Selected Publications
Notable Research Awards & Grants From Past 5 Years
Selected Publications
Low S, Pek S, Moh A, Ang K, Khoo J, Shao YM, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC. Triglyceride-glucose index is prospectively associated with chronic kidney disease progression in type 2 diabetes – mediation by pigment epithelium-derived factor. Diab Vasc Dis Res 2022; 19: 14791641221113784
Low S, Goh KS, Ng TP, Moh A, Ang SF, Wang J, Ang K, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC. Association between use of sodium-glucose co-transporter-2 (SGLT2) inhibitors and cognitive function in a longitudinal study of patients with type 2 diabetes. J Alzheimers Dis 2022; 87: 635-642
Low S, Goh KS, Ng TP, Moh A, Ang SF, Khoo J, Ang K, Yap P, Cheong CY, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC. Decline in skeletal muscle mass is associated with cognitive decline in type 2 diabetes mellitus. J Diabetes Complications 2022; 36: 108258
Low S, Wang J, Moh A, Ang SF, Ang K, Shao YM, Ching J, Wee HN, Lee LS, Kovalik JP, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC. Amino acid profile of skeletal muscle loss in type 2 diabetes: results from a 7-year longitudinal study in Asians. Diabetes Res Clin Pract 2022; 186: 109803
Low S, Pek S, Moh A, Khin CYA, Lim CL, Ang SF, Wang J, Ang K, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC. Low muscle mass is associated with progression of chronic kidney disease and albuminuria – An 8-year longitudinal study in Asians with Type 2 Diabetes. Diabetes Res Clin Pract 2021; 174: 108777
Low S, Pek S, Liu YL, Moh Am Ang K, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC. Higher extracellular water to total body water ratio was associated with chronic kidney disease progression in type 2 diabetes. J Diabetes Complications 2021; 35: 107930
Low S, Moh A, Ang SF, Lim CL, Liu YL, Wang J, Ang K, Tang WE, Kwan PY, Lim Z, Subramaniam T, Sum CF, Lim SC. The role of pulse pressure in navigating the paradigm of chronic kidney disease progression in type 2 diabetes mellitus. J Nephrol 2021; 34: 1429-1444
Low S, Ng TP, Lim CL, Ang SF, Moh A, Wang J, Yap P, Cheong CY, Goh KS, Ang K, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC. Higher ratio of extracellular water to total body water was associated with reduced cognitive function in type 2 diabetes. J Diabetes 2021; 13: 222-231
Low S, Ng TP, Lim CL, Wang J, Moh A, Ang SF, Goh KS, Ang K, Tang WE, Kwan PY, Lim Z, Subramaniam T, Sum CF, Lim SC. Association between vascular measures and cognitive function in type 2 diabetes. J Diabetes Complications 2020; 34: 107724
Low S, Ng TP, Lim CL, Moh A, Ang SF, Wang J, Goh KS, Ang K, Tang WE, Kwan PY, Subramaniam T, Sum CF, Lim SC. Association between lower extremity skeletal muscle mass and impaired cognitive function in type 2 diabetes. Sci Rep 2020; 10: 2956
Low S, Goh KS, Ng TP, Ang SF, Moh A, Wang J, Ang K, Subramaniam T, Sum CF, Lim SC. The prevalence of sarcopenic obesity and its association with cognitive performance in type 2 diabetes in Singapore. Clin Nut 2019; 39: 2274-2281
Low S, Khoo KCJ, Wang J, Irwan B, Sum CF, Subramaniam T, Lim SC, Wong TKM. Development of a metabolic syndrome severity score and its association with incident diabetes in an Asian population – results from a longitudinal cohort in Singapore. Endocrine 2019; 65: 73-80
Low S, Zhang X, Wang J, Yeoh LY, Liu YL, Ang SF, Subramaniam T, Sum CF, Lim SC. Impact of haemoglobin A1c trajectories on chronic kidney disease progression in type 2 diabetes. Nephrology (Carlton) 2019; 24: 1026-1032
Low S, Khoo KCJ, Irwan B, Sum CF, Subramaniam T, Lim SC, Wong TKM. The role of triglyceride glucose index in development of type 2 diabetes mellitus. Diabetes Res Clin Pract 2018; 143:43-49
Low S, Zhang X, Wang J, Yeoh LY, Liu YL, Ang KKL, Tang WE, Kwan PY, Tavintharan Subramaniam, Sum CF, Lim SC. Long-term prospective observation suggests that glomerular hyperfiltration is associated with rapid decline in renal filtration function: a multiethnic study. Diab Vasc Dis Res 2018; 15: 417-423
Low S, Zhang X, Ang K, Yeo SJD, Lim GJ, Yeoh LY, Liu YL, Subramaniam T, Sum CF, Lim SC. Discovery and validation of serum creatinine variability as novel biomarker for predicting onset of albuminuria in type 2 diabetes mellitus. Diabetes Res Clin Pract 2018; 138: 8-15
Notable Research Awards & Grants From Past 5 Years
Name of Awards | Year Obtained |
National Medical Research Council Transition Award | 2025 |
NHG-LKCMedicine Clinician Scientist Career Scheme | 2025 |
Singapore Clinical Investigator Award Category in Singapore Health and Biomedical Congress (Silver) | 2022 |
Singapore Clinical Investigator Award Category in Singapore Health and Biomedical Congress (Bronze) | 2021 |
Best Poster for Clinical Research Category in Singapore Health and Biomedical Congress (Gold) | 2021 |
Best Oral Presentation Award for Senior Clinical Research Category in SingHealth Duke-NUS Scientific Congress (Winner) | 2021 |
Best Oral Presentation Award in ASEAN Federation of Endocrine Societies Investigator (Winner) | 2019 |
Singapore Clinical Investigator Award Category in Singapore Health and Biomedical Congress (Gold) | 2019 |
ASEAN Federation of Endocrine Societies Investigator Award (Winner) | 2018 |
Best Poster for Basic Science/Translational Research Category in Singapore Health and Biomedical Congress (Silver) | 2018 |
Name of Grants | Year Obtained |
Science – Translational & Applied Research (STAR) II grant of $163,693.34. Study on the longitudinal association between body composition and cognitive decline in type 2 diabetes with exploration of the underlying inflammatory pathway | 2023 |
Science - Translational & Applied Research (STAR) II grant of $496,850.00. The role of sodium-glucose co-transporter-2 inhibitor on renal trajectories in patients with type 2 diabetes and chronic kidney disease | 2022 |
Science - Translational & Applied Research (STAR) I grant of $72,000. A study on the role of muscle-fat ratio in the paradigm of reduced cognitive function in type 2 diabetes | 2021 |
Science - Translational & Applied Research (STAR) I grant of $100,000. Navigating the paradigm of testosterone deficiency in men with Type 2 Diabetes – interplay of sex hormones, body composition and diabetic complications | 2020 |
Science - Translational & Applied Research (STAR) I grant of $99,995. Navigating the Paradigm of Diabetes Mellitus in the Elderly – Unravelling the Interplay between Hyperglycemia, Body Composition and Frailty | 2019 |
Science - Translational & Applied Research (STAR) Il grant of $202,528. Economic burden of progressive Type 2 Diabetes and its complications in Singapore – direct, indirect and intangible costs | 2019 |
National Medical Research Council Research Training Fellowship | 2019 |
Science - Translational & Applied Research (STAR) I grant of $99,980. Normal Reference Range for Glycemic Variability for Individuals without Diabetes in Singapore | 2018 |
