The Psoriasis Unit attends to psoriasis patients - particularly those with severe disease. Modalities of treatment used include topical coal tar, dithranol, calcipotriol and topical steroids. Patients who require phototherapy are sent to the Phototherapy Unit for further management. Systemic therapy used include MTX, retinoids, ciclosporin and others.

The unit is actively involved in research in Psoriasis. The spectrum of research activities include clinical trials, epidemiological studies and basic research on psoriasis.

The unit also works with the Psoriasis Association of Singapore (PAS), a self-help support group.