This guide helps chemotherapy patients manage hand-foot syndrome, a side effect causing redness, pain, and swelling on palms and soles. It provides practical prevention strategies including avoiding high-stress activities like long walks or manual labor, protecting skin from hot water and harsh chemicals, and soothing affected areas with moisturizers, cool compresses, and padded shoes. The material emphasizes seeking medical attention for signs of infection, severe symptoms, or inability to perform daily activities.