This guide educates patients taking antiresorptive medications (for fragile bones or cancer) about preventing medication-related osteonecrosis of the jaw (MRONJ), a rare condition causing exposed, infected bone after tooth extraction. It explains MRONJ risk levels, emphasizes preventive oral hygiene including twice-daily brushing with fluoride toothpaste, daily flossing, low-sugar diet, regular dental check-ups, and the importance of pre-treatment dental evaluations to address infections before starting antiresorptive therapy.