Dr Samuel Lee obtained his basic medical degree in 2012 from the National University of Singapore and obtained his postgraduate degree in Internal Medicine in 2016. He was accredited as a specialist in Rheumatology and admitted as a Fellow of the Academy of Medicine Singapore in 2020. In 2023, he completed further speciality training in Clinical Immunology and Allergy. He was awarded the Tan Tock Seng Hospital Training and Development Award in 2024 and completed a clinical fellowship in Autoinflammatory Diseases and Inborn Errors of Immunity at the Royal Free Hospital in London, United Kingdom.

His clinical practice encompasses the overlapping specialities of rheumatology, clinical immunology and allergy, and the application of clinical genetics in these areas. He has a special interest in treating patients with autoinflammatory, immunodeficiency and primary immune regulatory disorders.

Dr Lee is the current Programme Director of the NHG Health Rheumatology Senior Residency programme. He is also an educator with the Yong Loo Lin School of Medicine and the Lee Kong Chian School of Medicine. He has served on the executive committees of professional societies such as the Singapore Society of Rheumatology and the Allergy and Clinical Immunology Society of Singapore.