General Surgery, Tan Tock Seng Hospital
Head of Service
Breast & Endocrine Surgery
Head of Service
Breast & Endocrine Surgery
A/Prof Tan Ern Yu graduated from the National University of Singapore in 1999.
She earned her Masters of Medicine from her alma mater in 2003. A/Prof Tan Ern Yu has also obtained her fellowship with the Royal College of Surgeons in Edinburgh, United Kingdom and the Academy of Medicine, Singapore in the same year.
A/Prof Tan is a NMRC clinician scientist and obtained a DPhil from the University of Oxford in 2007. She is involved in several national level grants and consortium and collaborates with international institutes and industry partners. She is currently the Director of Clinical Research at Tan Tock Seng Hospital. Her research interests include biomarker discovery and development for breast cancer and high-risk breast diseases, and Artifical Intelligence applications in breast imaging and data analytics.
A/Prof Tan is the current Director of the Breast Clinic and her area of clinical interests includes General Surgery, Breast and Endocrine Surgery.
Publications
1. Post-Operative Radiation in Early Breast Cancer with N1 Disease: 10-Year Follow-Up.
2. Evaluating treatment outcomes in women with node-negative T1 breast cancers.
3. Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: In-vitro and in-silico 3D tumour spheroid studies.
4. Impact of deviation from guideline recommended treatment on breast cancer survival in Asia.
5. EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
6. Preliminary local experience with breast magnetic resonance imaging on surgical planning and outcomes.
7. Idiopathic granulomatous mastitis: A retrospective cohort study of clinical course and treatment modalities in 77 patients.
8. Contrast Enhanced Mammogram: A new game-change in Breast Imaging. Indications with Case based experience.
9. Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers.
10. Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.
11. Polygenic risk scores for prediction of breast cancer risk in Asian populations.
12. DNA methylation and breast cancer-associated variants.
13. Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival.
14. Predicting the Likelihood of Carrying a BRCA1 or BRCA2 Mutation in Asian Patients With Breast Cancer.
15. Mammography screening is associated with more favourable breast cancer tumour characteristics and better overall survival: case-only analysis of 3739 Asian breast cancer patients.
16. Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification.
17. IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer.
18. Hypoxia induces HIF1a-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy.
19. Impact of Subsidy on the Use of Personalized Medicine in Breast Cancer.
20. Deep learning applied to breast imaging classification and segmentation with human expert intervention.
21. Relevance of the MHC region for breast cancer susceptibility in Asians.
22. How Asian Breast Cancer Patients Experience Unequal Incidence of Chemotherapy Side Effects: A Look at Ethnic Disparities in Febrile Neutropenia Rates
23. Label-free detection of MiRNA biomarkers using broadband multi-resonant infrared metasurfaces for early breast cancer diagnosis
24. Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
25. A novel survival prediction signature outperforms PAM50 and artificial intelligence-based feature-selection methods
26. Genomic Insights into Idiopathic Granulomatous Mastitis through Whole-Exome Sequencing: A Case Report of Eight Patients.
27. Characterizing the Relationship between Expression Quantitative Trait Loci (eQTLs), DNA Methylation Quantitative Trait Loci (mQTLs), and Breast Cancer Risk Variants.
28. Complete characterization of RNA biomarker fingerprints using a multi-modal ATR-FTIR and SERS approach for label-free early breast cancer diagnosis.
