
Important Notice
The medication images on this site are sourced from NHG Health’s internal formulary and are provided solely for identification and educational purposes. They may not represent all available brands, formulations, or packaging of medications registered in Singapore. While reasonable efforts have been made to ensure the images accurately reflect the actual medications, colour, shape, and appearance may vary due to manufacturing differences, batch variations, and display settings.
A combination of paracetamol and orphenadrine is commonly used to treat muscle pain. Orphenadrine is a muscle relaxant and paracetamol is used to relieve pain.
You may take this medication with or without food.
Do not take more than two tablets at any time and make sure to space each dose at least four hours apart.
Do not exceed six tablets in 24 hours.
- Do not take other paracetamol-containing products while on this medication to prevent overdose.
- Combination tablets containing paracetamol and orphenadrine are generally taken on an as-needed basis. Take them regularly only when directed by the doctor.
- If you forget to take a dose, take it as soon as you remember if it is not close to the next dose. Otherwise, you should skip the dose and take the next dose at the usual time. Do not take two doses together to make up for the missed dose.
Inform your healthcare professional if:
You are allergic to paracetamol or any of the other ingredients of this medication.
You have a history of
Liver condition
Glaucoma (abnormally high pressure in the eye)
Urinary condition or not being able to empty your bladder
Enlarged prostate
Myasthenia Gravis (an immune disease that causes muscle weakness)
You are pregnant, planning to become pregnant, or breastfeeding.
- You are taking any other medications, including supplements, traditional medications and herbal remedies.
If you have any question about this medication, please discuss with your healthcare professional.
• Drowsiness
o Avoid driving or engaging in activities that require concentration
• Nausea
o Take the medication with or after food to reduce nausea
• Dizziness
o Avoid driving or engaging in activities that require concentration
• Dry mouth
• Dry eyes
The symptoms of a drug allergy include one or more of the following:
- Swollen face/eyes/lips/tongue
- Difficulty in breathing
- Itchy skin rashes over your whole body
Other rare but serious effects that may occur include:
- Retention of urine
- Persistently fast heartbeat
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Avoid taking alcohol with paracetamol and orphenadrine as it may cause too much drowsiness.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
Disclaimer
The content of this article does not replace the information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore (PSS).
The images and video in this article has been developed by the Singapore National Asthma Programme (SNAP) and have been reviewed by the PSS-National Medication Information workgroup.

