This guide provides essential information for patients undergoing spleen removal surgery (splenectomy). It explains why spleen removal may be necessary, the increased infection risk afterward, and critical prevention strategies including specific vaccinations (pneumococcal, Hib, meningococcal). The material covers when to seek immediate medical care, travel precautions especially for malaria-endemic areas, and emphasizes the importance of carrying a medical alert card identifying the patient's splenectomy status.